ISOLATION AND STANDARDIZATION OF GLYCYRRHIZIC ACID FROM LICORICE DRY EXTRACTS

Extraction of Glycyrrhizic Acid and Glabridin from Licorice

The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50 degrees C. The extracts of licorice were separated and det...

Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars.

A 49-year-old female physician presented with peripheral edema, weight gain and relative hypertension caused by the consumption of licorice candy cigars containing glycyrrhizic acid (GZA) found in natural licorice extract. Although the patient's response to GZA resolved spontaneously, emergency physician awareness of the toxic effects of natural licorice extract may avert symptom progression in...

Effect of Ethanol Concentration in Ultrasound Assisted Extraction of Glycyrrhizic Acid from Licorice Root

Optimization of the Glycyrrhizic Acid Extraction from Licorice by Response Surface Methodology

This study aims to extract Glycyrrhizic Acid (GA) from Glycyrrhiza glabra L. (licorice) using a novel, high efficiency, and low-cost extraction method. Water was chosen as the proper solvent for the extraction process to eliminate the requirement of harmful and toxic solvents, prepare an environmentally friendly process, and reduce the costs. The effect of differe...

Optimization of ultrasound-assisted extraction of glycyrrhizic acid from licorice using response surface methodology

Background The present study optimized ultrasound-assisted extraction conditions to maximize extraction yields of glycyrrhizic acid from licorice. Methods The optimal extraction temperature (X1), extraction time (X2), and methanol concentration (X3) were identified using response surface methodology (RSM). A central composite design (CCD) was used for experimental design and analysis of the r...